Tolvaptan
Tolvaptan is a selective vasopressin V2 receptor antagonist active pharmaceutical ingredient widely used for the treatment of hyponatremia associated with heart failure, cirrhosis, and syndrome of inappropriate antidiuretic hormone secretion (SIADH), as well as for slowing kidney function decline in autosomal dominant polycystic kidney disease (ADPKD). By blocking V2 receptors in the renal collecting ducts, Tolvaptan promotes aquaresis—selective excretion of free water—helping restore normal sodium levels and reduce fluid overload. Pharmaceutical companies formulate Tolvaptan into oral tablets, providing precise dosing for chronic and acute therapy.
Common Tolvaptan Uses and Treated Conditions
- Hyponatremia – Corrects low blood sodium levels associated with heart failure, cirrhosis, or SIADH.
- Autosomal Dominant Polycystic Kidney Disease (ADPKD) – Slows progression of kidney cyst growth and preserves renal function.
- Fluid Management – Supports management of fluid overload in patients with congestive conditions.
Why Choose Cambrex as Your Generic API Manufacturer?
As a leading generic API supplier, Cambrex manufactures Tolvaptan API in cGMP-compliant facilities, ensuring every batch meets stringent global quality and regulatory standards. Our technical expertise, robust quality systems, and proven regulatory track record empower clients to accelerate development timelines and achieve successful market approvals. We prioritize transparency, reliability, and scientific rigor at every stage of the supply chain making us your trusted generic API manufacturer.
For detailed chemical information on Tolvaptan, visit the official CAS website.
If you’d like more information or to request a sample, contact our Generic API team today.


Cambrex your API partner
Cambrex are a leading global supplier of generic APIs. From our sites in Italy, Sweden, and the USA, we work with generic drug companies well in advance of drug patent expiration, using high quality, non-patent-infringing processes to manufacture APIs.
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