At Cambrex, it’s our people that set us apart. We work locally and have an impact globally. We’re committed to attracting, nurturing and retaining a passionate and talented team of experts in our fast paced and growing company. You will be valued and recognized. We offer an exceptional benefits package including medical, dental, vision, Life, LTD, generous vacation in your first year, sick time, and retirement savings!
Cambrex is the small molecule company that provides drug substance, drug product and analytical services across the entire drug lifecycle. Known for our scientific and manufacturing excellence and customer focus, we offer a range of career opportunities across our global network of locations. As a team, we share one goal – to improve the quality of life for our customers’ patients across the world.
This role is focused on design of experiments (DOE) toward optimization of early to late-stage chemical routes toward commercial manufacture of pharmaceutical APIs. Primary responsibilities will include design of the experimental DOE plan, direction of experimental efforts for DOE scientists, and hands-on laboratory execution of the approved plan. This position will also be responsible for organizing weekly team meetings with clients and providing summary R&D reports at the conclusion of DOE projects.
► Use of DOE software such as MODDE, JMP, MINITAB, etc. to successfully design and execute a multivariate experimental plan (Taguchi, Plackett Burman, etc) toward identification of ideal process conditions and critical process parameters (CPP).
► Process Research and Development; design and carry out multistep organic syntheses, including isolation, purification, and data analysis summary for completed work
► Must possess a strong understanding of modern organic synthesis methodologies
► Must have a thorough understanding of modern analytical and spectroscopic techniques, and must possess the ability to interpret the corresponding data and spectra. In addition, should be able to conduct literature searches for specific target compounds and/or be able to use the literature to base a design of alternate routes to these compounds. Should keep abreast of current scientific literature and discuss these findings with colleagues.
► Must demonstrate a proficiency to carry out laboratory syntheses and purification techniques on scales ranging from milligrams to several kilograms, and design and implement appropriate process modifications.
► Should require minimal supervision and be able to successively complete projects while working independently or within a matrix-based team.
► Should be able to multi-task and effectively handle multiple projects at once
► Should be able to mentor and direct research activities of junior staff at Research Assistant to Associate Principal Scientist level and may be asked to organize the efforts for a matrix team of higher level scientists in DOE efforts.
► Must be able to organize work time efficiently so that several operations can be carried out simultaneously.
► Demonstrate ability to write comprehensive reports at the conclusion of projects for internal and customer use.
► Work closely with other chemistry and analytical laboratory staff to coordinate project activities and resource usage.
► Work to ensure that a spirit of teamwork and cooperation exists within the group at all times.
► Conduct laboratory operations in a safe manner. Maintain familiarity with the company’s chemical hygiene plan. Exhibit safety awareness and safe work practices.
► Follow responsible actions regarding chemical disposal. Maintain compliance with all regulations at the federal, state, and local levels.
- D. Organic Chemistry or Equivalent degree with at least 8 years of hands-on experience in pharmaceutical/chemical process development. Proven track record and experience with expertise in utilization of DOE software for design, modeling, and assessment of data for late-stage programs.
- S. in Chemistry, Organic Chemistry, or Medicinal Chemistry with at least 12 years of hands-on experience in pharmaceutical/chemical process development. Proven track record and experience with expertise in utilization of DOE software for design, modeling, and assessment of data for late-stage programs.
- B. S. in Chemistry with at least 14 years of hands-on experience in pharmaceutical/chemical process development. Proven track record and experience with expertise in utilization of DOE software for design, modeling, and assessment of data for late-stage programs.