Understanding the importance of crystallization processes to avoid unnecessary cost, risk and development delays
Wednesday May 27, 2020 – 10am EST/ 4pm CET
Cambrex will be hosting a live webinar on understanding the importance of crystallization processes to avoid unnecessary cost, risk and development delays and we would like to invite you to join us.
Dr Craig Callahan, Project Scientist, Cambrex Edinburgh
Crystallization is often the ultimate step of a drug substance manufacturing process prior to isolation and drying. A robust crystallization process can allow many benefits, such as isolation of a desired polymorphic form, optimization of purity through exclusion of impurities, and enhanced yield. Additionally, a crystallization process can allow physical properties of a batch of particles to be optimized. An API’s particle size distribution, particle morphology and flow properties can also have a significant impact on the downstream processing that it will have to endure en-route to a formulated drug product. Filtration, washing, drying and formulation can all be enhanced, and product consistency improved, by adopting a suitable, well developed crystallization process that targets suitable particles by design.
This webinar will:
- Provide an introduction and overview of the importance of crystallization in the pharmaceutical industry
- Discuss the workflow of a crystallization process development program at Cambrex Edinburgh
- Consider examples of typical issues faced during the crystallization process development of an API
- Discuss case studies where careful control of the crystallization has allowed processing problems to be overcome
Cambrex’s Edinburgh site is a world-leader in providing solid form development services for drug substance and drug product.