We work closely to understand customer needs and provide input and guidance along the continuum of hit identification through preclinical candidate selection and product differentiation. Our experienced team can handle complex projects and deliver development candidates across a variety of therapeutic areas.
The complex process of transforming a hit molecule into a clinical candidate requires a broad range of technical skills and capabilities. Cambrex seamlessly integrates Medicinal Chemistry, Computational Chemistry, Analytical Chemistry, ADMET-PK, Biological Assay, Development Validation and Testing, and Bioanalytical Chemistry into focused research teams to meet the requirements of your Target Product Profile in a timely and efficient manner.
Animal Health Capabilities
Each lead optimization process is tailored to a specific Target Product Profile for the appropriate disease indication. Our multidisciplinary discovery teams (consisting of biology, chemistry and DMPK scientists) advance compound series from preclinical into clinical candidate nomination stage. Our world class team of scientists are experienced in the unique requirements of animal health drugs and markets.
Medicinal chemists design and synthesize new compounds to optimize biological activity and physicochemical properties. Biologists develop screening paradigms to assess compounds in order to develop a biological profile including potency and selectivity. DMPK scientists perform assays and studies to understand the disposition and pharmacokinetics of the compounds.
The integration of these disciplines, coupled with the team’s particular expertise in animal health, enables the design and selection of new chemical entities that meet the market needs of clients and anticipate areas for future strategic collaboration.
Cambrex Best-in-Class Animal Health Capabilities Include:
- Integrated teams with proven success in drug discovery
- Experienced Biologists, Chemists and DMPK Scientists
- Parasiticide Discovery (endoparasites, ectoparasites, protozoans, and disease vectors)
- Novel in vitro whole organism assays
- Developed and validated screening cascades
- Proprietary in vivo models of disease
- Therapeutic Discovery for companion animals
- Compound selection and workflow management
- Sample and data management
- Network of animal health experts and key opinion leaders
Animal Health Parasiticide Platform
Our state-of-the-art parasiticide platform supports the discovery and development of products for companion and production animals. Cambrex bio-profiling portfolio includes 40 species of clinically and commercially important ectoparasites (fleas, ticks, flies, mosquitos) and endoparasites (intestinal worms, heartworms), as well as protozoans (leishmania, cryptosporidium, trypanosomes). Cambrex has the capability to screen large compound collections in a high-throughput screening format or focused compound sets to support lead optimization, candidate selection and label extension. Cambrex has a proven record of success in the identification and optimization of parasiticides, with several candidates progressing into clinical studies and commercialization.
|Species||Common Name/Diseases||Host Animal/Vector|
|Brugia malayi||Lymphatic filariasis||Human|
|Dirofilaria immitis**||Canine Heartworm||Dog|
|Litomosoides sigmodontis||Mouse Filarial Worm||Mouse/Jird|
|Haemonchus contortus**||Barber’s Pole Worm||Ruminants|
|Cooperia punctata||Small Intestinal Worm||Ruminants|
|Cooperia onchophora||Small Intestinal Worm||Ruminants|
|Ostertagia ostertagi||Small Brown Stomach Worm||Ruminants|
|Trichostrongylus colubriformis**||Intestinal Hair Worm||Ruminants|
|Trichuris muris*||Mouse Whipworm||Mouse|
|Fasciola hepatica*||Common Liver Fluke||Cattle/Human|
|Trypanosoma brucei brucei||Human African Trypanosomiasis||Human/Cattle|
|Trypanosoma cruzi||Chagas Disease||Human/Dog|
|Trypanosoma evansi||Animal Trypanosomiasis||Cattle/Equine|
|Trypanosoma congolense||African Animal Trypanosomiasis||Cattle|
|Leishmania donovani||Visceral leishmaniasis||Human|
|Leishmania major||Cutaneous leishmaniasis||Human|
|Leishmania infatum||Visceral leishmaniasis||Human/Dogs|
|Giardia lamblia*||Diarrheal disease/Giardiasis||Human/Cat/Dog|
|Tritrichomonas foetus*||Diarrheal disease||Cattle/Cat|
|Stomoxys calcitrans||Stable Fly||Cattle/Horse|
|Haematobia irritans**||Horn Fly||Cattle/Horse|
|Lucilia spp||Blow Fly||Cattle/Horse/Sheep|
|Musca autumnalis||Face Fly||Cattle/Horse/Sheep|
|Musca domestica**||House Fly||—|
|Ctenocephalides felis||Cat Flea||Dog/Cat|
|Rhipicephalus sanguineus||Brown Dog Tick||Dog|
|Dermacentor variabilis||American Dog Tick||Dog|
|Amblyomma americanum||Lone Star Tick||Dog|
|Ixodes scapularis||Deer tick or blacklegged tick||Dog/Deer|
|Dengue Virus||Dengue Fever||Human|
|Aedes aegypti||Yellow Fever Mosquito||—|
|Anopheles quadrimaculatus||Common Malaria Mosquito||—|
|Anopheles gambiae**||African Malaria Mosquito||—|
|Culex quinquefasciatus||Southern House Mosquito||—|
**Resistant and Susceptible Species
Find out more
To learn more about our animal health discoveries, get in touch through our contact page.