Animal health discovery

We work closely to understand customer needs and provide input and guidance along the continuum of hit identification through preclinical candidate selection and product differentiation. Our experienced team can handle complex projects and deliver development candidates across a variety of therapeutic areas.

The complex process of transforming a hit molecule into a clinical candidate requires a broad range of technical skills and capabilities. Cambrex seamlessly integrates Medicinal Chemistry, Computational Chemistry, Analytical Chemistry, ADMET-PK, Biological Assay, Development Validation and Testing, and Bioanalytical Chemistry into focused research teams to meet the requirements of your Target Product Profile in a timely and efficient manner.

Animal Health Capabilities

Each lead optimization process is tailored to a specific Target Product Profile for the appropriate disease indication. Our multidisciplinary discovery teams (consisting of biology, chemistry and DMPK scientists) advance compound series from preclinical into clinical candidate nomination stage. Our world class team of scientists are experienced in the unique requirements of animal health drugs and markets.

Medicinal chemists design and synthesize new compounds to optimize biological activity and physicochemical properties. Biologists develop screening paradigms to assess compounds in order to develop a biological profile including potency and selectivity. DMPK scientists perform assays and studies to understand the disposition and pharmacokinetics of the compounds.

The integration of these disciplines, coupled with the team’s particular expertise in animal health, enables the design and selection of new chemical entities that meet the market needs of clients and anticipate areas for future strategic collaboration.

Cambrex Best-in-Class Animal Health Capabilities Include:

  • Integrated teams with proven success in drug discovery
  • Experienced Biologists, Chemists and DMPK Scientists
  • Parasiticide Discovery (endoparasites, ectoparasites, protozoans, and disease vectors)
  • Novel in vitro whole organism assays
  • Developed and validated screening cascades
  • Proprietary in vivo models of disease
  • Therapeutic Discovery for companion animals
  • Compound selection and workflow management
  • Sample and data management
  • Network of animal health experts and key opinion leaders

Animal Health Parasiticide Platform

Our state-of-the-art parasiticide platform supports the discovery and development of products for companion and production animals. Cambrex bio-profiling portfolio includes 40 species of clinically and commercially important ectoparasites (fleas, ticks, flies, mosquitos) and endoparasites (intestinal worms, heartworms), as well as protozoans (leishmania, cryptosporidium, trypanosomes). Cambrex has the capability to screen large compound collections in a high-throughput screening format or focused compound sets to support lead optimization, candidate selection and label extension. Cambrex has a proven record of success in the identification and optimization of parasiticides, with several candidates progressing into clinical studies and commercialization.

Species List:

SpeciesCommon Name/DiseasesHost Animal/Vector
Endoparasites
Brugia malayiLymphatic filariasisHuman
Dirofilaria immitis**Canine HeartwormDog
Litomosoides sigmodontisMouse Filarial WormMouse/Jird
Haemonchus contortus**Barber’s Pole WormRuminants
Cooperia punctataSmall Intestinal WormRuminants
Cooperia onchophoraSmall Intestinal WormRuminants
Ostertagia ostertagiSmall Brown Stomach WormRuminants
Trichostrongylus colubriformis**Intestinal Hair WormRuminants
Strongyloides stercoralisThreadwormHuman/Dog
Trichuris muris*Mouse WhipwormMouse
Ancylostoma ceylanicum*HookwormHuman
Schistosoma mansoniSchistosomiasisHuman
Fasciola hepatica*Common Liver FlukeCattle/Human
Cryptosporidium parvumCryptosporidiosisHuman/Cattle
Trypanosoma brucei bruceiHuman African TrypanosomiasisHuman/Cattle
Trypanosoma cruziChagas DiseaseHuman/Dog
Trypanosoma evansiAnimal TrypanosomiasisCattle/Equine
Trypanosoma congolenseAfrican Animal TrypanosomiasisCattle
Leishmania donovaniVisceral leishmaniasisHuman
Leishmania majorCutaneous leishmaniasisHuman
Leishmania infatumVisceral leishmaniasisHuman/Dogs
Plasmodium falciparum**MalariaHuman
Giardia lamblia*Diarrheal disease/GiardiasisHuman/Cat/Dog
Toxoplasma gondii*ToxoplasmosisHuman
Tritrichomonas foetus*Diarrheal diseaseCattle/Cat
Ectoparasites
Stomoxys calcitransStable FlyCattle/Horse
Haematobia irritans**Horn FlyCattle/Horse
Lucilia sppBlow FlyCattle/Horse/Sheep
Musca autumnalisFace FlyCattle/Horse/Sheep
Musca domestica**House Fly
Ctenocephalides felisCat FleaDog/Cat
Rhipicephalus sanguineusBrown Dog TickDog
Dermacentor variabilisAmerican Dog TickDog
Amblyomma americanumLone Star TickDog
Ixodes scapularisDeer tick or blacklegged tickDog/Deer
Viruses
Dengue VirusDengue FeverHuman
Vectors
Aedes aegyptiYellow Fever Mosquito
Anopheles quadrimaculatusCommon Malaria Mosquito
Anopheles gambiae**African Malaria Mosquito
Culex quinquefasciatusSouthern House Mosquito

*In Development

**Resistant and Susceptible Species

Find out more

To learn more about our animal health discoveries, get in touch through our contact page.

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