Animal health discovery

We work closely to understand customer needs and provide input and guidance along the continuum of hit identification through preclinical candidate selection and product differentiation. Our experienced team can handle complex projects and deliver development candidates across a variety of therapeutic areas.

The complex process of transforming a hit molecule into a clinical candidate requires a broad range of technical skills and capabilities. Cambrex seamlessly integrates Medicinal Chemistry, Computational Chemistry, Analytical Chemistry, ADMET-PK, Biological Assay, Development Validation and Testing, and Bioanalytical Chemistry into focused research teams to meet the requirements of your Target Product Profile in a timely and efficient manner.

Animal Health Capabilities

Each lead optimization process is tailored to a specific Target Product Profile for the appropriate disease indication. Our multidisciplinary discovery teams (consisting of biology, chemistry and DMPK scientists) advance compound series from preclinical into clinical candidate nomination stage. Our world class team of scientists are experienced in the unique requirements of animal health drugs and markets.

Medicinal chemists design and synthesize new compounds to optimize biological activity and physicochemical properties. Biologists develop screening paradigms to assess compounds in order to develop a biological profile including potency and selectivity. DMPK scientists perform assays and studies to understand the disposition and pharmacokinetics of the compounds.

The integration of these disciplines, coupled with the team’s particular expertise in animal health, enables the design and selection of new chemical entities that meet the market needs of clients and anticipate areas for future strategic collaboration.

Cambrex Best-in-Class Animal Health Capabilities Include:

  • Integrated teams with proven success in drug discovery
  • Experienced Biologists, Chemists and DMPK Scientists
  • Parasiticide Discovery (endoparasites, ectoparasites, protozoans, and disease vectors)
  • Novel in vitro whole organism assays
  • Developed and validated screening cascades
  • Proprietary in vivo models of disease
  • Therapeutic Discovery for companion animals
  • Compound selection and workflow management
  • Sample and data management
  • Network of animal health experts and key opinion leaders

Animal Health Parasiticide Platform

Our state-of-the-art parasiticide platform supports the discovery and development of products for companion and production animals. Cambrex bio-profiling portfolio includes 40 species of clinically and commercially important ectoparasites (fleas, ticks, flies, mosquitos) and endoparasites (intestinal worms, heartworms), as well as protozoans (leishmania, cryptosporidium, trypanosomes). Cambrex has the capability to screen large compound collections in a high-throughput screening format or focused compound sets to support lead optimization, candidate selection and label extension. Cambrex has a proven record of success in the identification and optimization of parasiticides, with several candidates progressing into clinical studies and commercialization.

Species List:

Species Common Name/Diseases Host Animal/Vector
Endoparasites
Brugia malayi Lymphatic filariasis Human
Dirofilaria immitis** Canine Heartworm Dog
Litomosoides sigmodontis Mouse Filarial Worm Mouse/Jird
Haemonchus contortus** Barber’s Pole Worm Ruminants
Cooperia punctata Small Intestinal Worm Ruminants
Cooperia onchophora Small Intestinal Worm Ruminants
Ostertagia ostertagi Small Brown Stomach Worm Ruminants
Trichostrongylus colubriformis** Intestinal Hair Worm Ruminants
Strongyloides stercoralis Threadworm Human/Dog
Trichuris muris* Mouse Whipworm Mouse
Ancylostoma ceylanicum* Hookworm Human
Schistosoma mansoni Schistosomiasis Human
Fasciola hepatica* Common Liver Fluke Cattle/Human
Cryptosporidium parvum Cryptosporidiosis Human/Cattle
Trypanosoma brucei brucei Human African Trypanosomiasis Human/Cattle
Trypanosoma cruzi Chagas Disease Human/Dog
Trypanosoma evansi Animal Trypanosomiasis Cattle/Equine
Trypanosoma congolense African Animal Trypanosomiasis Cattle
Leishmania donovani Visceral leishmaniasis Human
Leishmania major Cutaneous leishmaniasis Human
Leishmania infatum Visceral leishmaniasis Human/Dogs
Plasmodium falciparum** Malaria Human
Giardia lamblia* Diarrheal disease/Giardiasis Human/Cat/Dog
Toxoplasma gondii* Toxoplasmosis Human
Tritrichomonas foetus* Diarrheal disease Cattle/Cat
Ectoparasites
Stomoxys calcitrans Stable Fly Cattle/Horse
Haematobia irritans** Horn Fly Cattle/Horse
Lucilia spp Blow Fly Cattle/Horse/Sheep
Musca autumnalis Face Fly Cattle/Horse/Sheep
Musca domestica** House Fly
Ctenocephalides felis Cat Flea Dog/Cat
Rhipicephalus sanguineus Brown Dog Tick Dog
Dermacentor variabilis American Dog Tick Dog
Amblyomma americanum Lone Star Tick Dog
Ixodes scapularis Deer tick or blacklegged tick Dog/Deer
Viruses
Dengue Virus Dengue Fever Human
Vectors
Aedes aegypti Yellow Fever Mosquito
Anopheles quadrimaculatus Common Malaria Mosquito
Anopheles gambiae** African Malaria Mosquito
Culex quinquefasciatus Southern House Mosquito

*In Development

**Resistant and Susceptible Species

Find out more

To learn more about our animal health discoveries, get in touch through our contact page.

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