Continuous flow

Expertise
Building on our multi-decade industrial experience, Cambrex offers continuous flow process development services to provide our customers with route scouting, process development, process optimization, or scale-up and commercialization depending upon the stage within a program’s lifecycle.

The benefits of our continuous flow process development services include:

• Enhanced purity and product quality through improved control
• Improved process safety, especially with toxic or energetic chemistries
• Ability to access and utilize extreme or exotic process conditions
• Lower operating costs
• Ability to incorporate constant real-time analytics
• Reduced process mass intensity
• Development of chemistry on a commercial-ready skid

Our team of experts can assess processes for suitable application of continuous flow culminating in the custom development of processes incorporating proof-of-concept to cGMP manufacturing and commercialization.

Capabilities

• Reaction kinetics screening
• Reaction condition development & optimization
• High pressure & high temperature capabilities
• Extreme cryogenic capabilities
• Multi-phase system capabilities
• Critical parameter identification
• Assessment of process analytical technologies (PAT) for monitoring & control
• Capture & provide robust process data packages to support further development
• Analytical method development & integration into continuous flow process
• Development of process-specific control & regulatory strategy
• Development of continuous extraction/separation/crystallization
• Incorporation of in-line wet milling to control particle size
• Telescoping of multiple continuous flow steps/unit operations
• Integrating individual flow steps within traditional batch processing
• Development of novel technologies & equipment to support client process needs
• Process-specific equipment design to maximize throughput, quality and scalability
• Process optimization & technology transfer
• Proof-of-concept & engineering campaigns
• Scale-up & manufacturing