IEP

Overview

Cambrex IEP is located in Wiesbaden, Germany and is a world leader in bioreduction technology.

Through efficient and environmentally friendly enzymatic syntheses, Cambrex IEP is able to supply highly pure regio-, chemo- and enantioselective intermediates and APIs for the pharmaceutical industry.

Cambrex IEP provides custom development and R&D screening, in addition to pilot to commercial scale cGMP capability for a wide range of chiral syntheses.

Services

• Screening for new enzymes
• Process development for chiral products
• Synthesis development
• Analytical development
• In-house process safety testing
• Technology laboratory (10 liter)
• Kilo lab
• Kilo scale manufacturing plant
• Pilot plant
• Molecular biology
  • Cloning
  • Over-expression, characterization and grouping of different enzymes
• Deliveries of chiral intermediates

Facility Details

For more than 10 years, Cambrex IEP has been developing extensive expertise in enzyme-catalyzed biotransformations with specific emphasis in bioreduction processes for commercial scale manufacturing.

Custom Services

• Customized biocatalytic process development based on collaborative efforts or as an R&D service
• Exclusive or non-exclusive licenses for established processes
• Screening using Cambrex‘s proprietary enzyme toolbox with customer substrates for feasibility studies and route evaluation
• Ongoing support through manufacturing including the training of personnel for working with enzymes

Custom Support

• Special cultivation and screening of wild-type organisms to discover new enzyme activities
• Isolation, purification and characterization of enzymes
• Cloning, recombinant over-expression and fermentation using proprietary in-house expression systems
• Biocatalytic process development to meet specific needs and preferences