Chiral synthesis

The importance of chirality in biological systems cannot be emphasized enough.

Cambrex has developed a large number of proprietary chiral compounds, especially in the area of chiral amines. Through the use of highly specialized enzymes that are produced by genetically engineered microorganisms, we can manufacture chiral amines with very high chiral purity, also on a commercial scale. Partnerships with research companies active in chiral technologies have given us access to a wide range of tools for the synthesis of different classes of chiral compounds.

Large scale enzymatic transformations

Enzymatic transformations are known for high efficiency on the molecular level, particularly when it comes to specificity and chiral purity. However, when it comes to production of large commercial quantities there are many limitations. The enzymes are active in only small pH and temperature ranges, only in water based systems, and are inactivated during the reaction. Moreover, they normally work only in dilute solutions, and the separation of the biological material from the reaction mixture is often tedious. 

Cambrex has developed processes for cGMP production of tens of tons of chiral molecules with enzymatic technologies. The goal is to become a world-leading producer of large quantities of chiral molecules. Through highly efficient processes and plants designed for high throughput, we strive to produce chiral compounds cost effectively.

**   under development
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