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| Cambrex North Brunswick |
General Information
| Cambrex North Brunswick, Inc. (CNB), North Brunswick, New Jersey, is dedicated to providing leading-edge products and services to the life sciences industry. These are offered to our customers; practitioners of R&D focused on drug targets, lead identification and lead optimization.
Now more than ever, there is a growing need to reduce the time it takes to bring a drug lead from the bench to the patient. CNB will work with you to redefine SPEED and assist you moving products to market FASTER.
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•Biocatalysis
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•Chiral Technology
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•Contract Research
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•Lead Identification
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•Lead Optimization
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•Process Development
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•Chemical Synthesis
CNB is a state-of-the-art facility to support small molecule drug discovery and development. Our services include cGMP Synthesis, Process Development, Analytical and Regulatory support, Biocatalysis, Synthetic Enzyme Development, General Chirality and the ability to perform R&D on Controlled Substances. Additionally we offer a Catalog of Chiral Amines. Our level of scale ranges from grams to tons and can easily take a development project from concept to proof-of-principle. Thereafter, the project can be seamlessly transferred to a Cambrex Subsidiary for commercialization.
Directions To CNB |
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cGMP Synthesis
| CNB houses a cGMP kilo lab with the ability to synthesize up to 20 kg of product. When customers require larger quantities, the process can be easily transferred to one of five other worldwide Cambrex sites with larger cGMP capacity. Cambrex Pharmaceuticals Group facilities adhere to the standards of the FDA´s current Good Manufacturing Practices (cGMP). |
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Process Development
| CNB is the epicenter for R&D within the Pharmaceuticals Group organization. CNB is ideal for early stage development projects and those that require clinical trial material up to 20 kg. We can assist with the scale-up of existing processes, the preparation of intermediate and kilogram quantities, process optimization in order to improve or modify an existing process, or the development of new routes to existing compounds. Once this early stage work is performed, customers have the choice of continuing to work with one of Cambrex´ worldwide commercial scale facilities. |
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Analytical and Regulatory Support
| An important component of many research projects involve analytical methods development and validation. CNB is equipped to provide customers with a comprehensive range of analytical services. These services include the development of stability indicating methods, isolation and identification of impurities, and routine analytical testing in compliance with cGMP regulations. The analytical laboratory is equipped with UV-Visible, FTIR, GLC, HPLC, and NMR instrumentation. The data generated by our analytical group is essential to the preparation and provision of Drug Master Files or Certificates of Suitability. |
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General Chirality
The majority of pharmaceutical New Chemical Entities (NCEs) under development are chiral with increasingly complex chemical structures. In addition to proprietary biotransformation technology, Cambrex practices classical resolution techniques, diastereomeric crystallizations, asymmetric chemical synthesis, and synthesis from the chiral pool, all to help establish the most efficient route to a given chiral target. Cambrex continues enhancing these technology platforms through internal development and external alliances with the goal to increase the tools available to access chirality.
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Biocatalysis
| Biocatalysis, the use of enzymes to catalyze a reaction, is a core expertise of Cambrex. Our staff of enzymologists and molecular biologists work along side organic chemists to determine if a biocatalytic route will streamline the chemical synthesis. Cambrex´ proprietary enzymatic transformation technology helps customers arrive at lower cost paths to their products. And in most cases, the ability to use conventional processing equipment significantly simplifies manufacturing. The result: more rapid implementation and less costly production. Cambrex offers biocatalysis screening services to customers either on a project specific basis or under an umbrella agreement. |
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Enzyme Development
 Cambrex uses protein engineering techniques in order to enhance enzyme performance. Key reaction parameters that can be improved through enzyme development include reaction rate, substrate affinity, product tolerance, enantioselectivity, reaction concentrations, and reaction equilibrium. Cambrex´s uses error-prone PCR to introduce changes into the protein structure. Then, through rapid screening, determine if these mutations have a positive impact on enzyme performance. This procedure is repeated until the desired level of improvement is reached. Cambrex is capable of improving customers´ enzymes, commercially available strains, or in-house proprietary enzymes. Cambrex´s proprietary enzymes include transamines and aldolases. |
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Controlled Substances
| For the past 10 years Cambrex companies have maintained both manufacturing and R&D licenses for a range of controlled substances, Schedules I - IV. With an excellent regulatory record and stringent adherence to DEA and FDA protocols, Cambrex provides a unique service to take your controlled substances project from grams to tons. |
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Directions to CNB
Cambrex North Brunswick, Inc.
Technology Center of New Jersey
661 Highway One
North Brunswick, NJ 08902
Phone: 732 447 1900
Fax: 732-447-1910
Location
We are located in the Technology Center of New Jersey, North Brunswick on Route 1 south, which is just south of Cook College and the Bristol Myers Squibb facility.
We are located in building 661, which is just behind the Chubb Institute Building. The directions are shown on brown signs with white text "New Jersey Tech Center" but they are sometimes difficult to spot. If you have a GPS the coordinates are: 40°28.11' N; 74°26.67' W.
Driving Directions
From the NJ Turnpike
On the Turnpike, exit 9 to Route 18 north. At Route 1 intersection (1/2 mile after TP exit) go Route 1 south. After Ryders Lane crossing (which is south of Route 18 intersection) exit right at DeVRY sign.
Make a left turn at the first local road and follow the road clockwise until you see building 661 on the left hand.
From southwest of New Brunswick (Route 1)
On Route 1 north, make an exit to the right at the DeVry sign. (you will have the DeVry building on the right hand). Follow the local road until it ends, go left thru the tunnel under Route 1. After the tunnel, take right at the second road. Follow the local road until you see building 661 on the right hand.
From northeast of New Brunswick (Route 1)
After Ryders Lane crossing (which is south of Route 18 intersection) exit right at DeVRY sign.
Make a left turn at the first local road and follow the road clockwise until you see building 661 on the left hand.
From northwest of New Brunswick (IS 287)
On IS 287 south exit 9 Easton Ave. south (3 miles). Take left at Landing La. Take right at first traffic light to George St.; continue to Route 18 south. Alternative: Exit 10 on IS 287 to River Rd south. Follow River Rd. to Route 18 south, take right over four-lane bridge and continue to Route 1 south. Exit to Route 1 south.
After Ryders Lane crossing (which is south of Route 18 intersection) exit right at DeVRY sign.
Make a left turn at the first local road and follow the road clockwise until you see building 661 on the left hand. |
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